GAR1 Antibody, FITC conjugated

Code CSB-PA878917LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GAR1 Polyclonal antibody
Uniprot No.
Target Names
GAR1
Alternative Names
Gar1 antibody; GAR1_HUMAN antibody; H/ACA ribonucleoprotein complex subunit 1 antibody; nucleolar protein family A member 1 (H/ACA small nucleolar RNPs) antibody; Nucleolar protein family A member 1 antibody; snoRNP protein GAR1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human H/ACA ribonucleoprotein complex subunit 1 protein (1-217AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Gene References into Functions
  1. The deregulated expression and function of H/ACA snoRNPs may underlie specific pathological features of human disease. PMID: 23707062
  2. The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. PMID: 19917616
  3. heterozygous point mutations in NOLA1 gene are not responsible for aplastic anemia in our patients at least acting via telomere PMID: 18989882
Subcellular Location
Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Protein Families
GAR1 family
Database Links

HGNC: 14264

OMIM: 606468

KEGG: hsa:54433

STRING: 9606.ENSP00000226796

UniGene: Hs.69851

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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